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Bredesen Protocol for Alzheimer's



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  • Bredesen Protocol for Alzheimer's
    Memory loss associated with Alzheimer’s reversed: Small trial succeeds using systems approach to memory disorders.

    “As one example, in the case of the patient with the demanding job who was forgetting her way home, her therapeutic program consisted of some, but not all of the components involved with Bredesen’s therapeutic program, and included:

    (1) eliminating all simple carbohydrates, leading to a weight loss of 20 pounds;
    (2) eliminating gluten and processed food from her diet, with increased vegetables, fruits, and non-farmed fish;
    (3) to reduce stress, she began yoga;
    (4) as a second measure to reduce the stress of her job, she began to meditate for 20 minutes twice per day;
    (5) she took melatonin each night;
    (6) she increased her sleep from 4-5 hours per night to 7-8 hours per night;
    (7) she took methylcobalamin each day;
    (8) she took vitamin D3 each day;
    (9) fish oil each day;
    (10) CoQ10 each day;
    (11) she optimized her oral hygiene using an electric flosser and electric toothbrush;
    (12) following discussion with her primary care provider, she reinstated hormone replacement therapy that had been discontinued;
    (13) she fasted for a minimum of 12 hours between dinner and breakfast, and for a minimum of three hours between dinner and bedtime;
    (14) she exercised for a minimum of 30 minutes, 4-6 days per week.”
    Reversal of cognitive decline: A novel therapeutic program

    Table 1. Therapeutic System 1.0

    Goal Approach Rationale and References
    Optimize diet: minimize simple CHO, minimize inflammation. Patients given choice of several low glycemic, low inflammatory, low grain diets. Minimize inflammation, minimize insulin resistance.
    Enhance autophagy, ketogenesis Fast 12 hr each night, including 3 hr prior to bedtime. Reduce insulin levels, reduce Aβ.
    Reduce stress Personalized—yoga or meditation or music, etc. Reduction of cortisol, CRF, stress axis.
    Optimize sleep 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if awakening. Exclude sleep apnea. [36]
    Exercise 30-60′ per day, 4-6 days/wk [37, 38]
    Brain stimulation Posit or related [39]
    Homocysteine 500 Me-B12 [41]
    CRP 1.5 Anti-inflammatory diet; curcumin; DHA/EPA; optimize hygiene Critical role of inflammation in AD
    Fasting insulin <7; HgbA1c <5.5 Diet as above Type II diabetes-AD relationship
    Hormone balance Optimize fT3, fT4, E2, T, progesterone, pregnenolone, cortisol [5, 42]
    GI health Repair if needed; prebiotics and probiotics Avoid inflammation, autoimmunity
    Reduction of Aβ Curcumin, Ashwagandha [43-45]
    Cognitive enhancement Bacopa monniera, MgT [46, 47]
    25OH-D3 = 50-100ng/ml Vitamins D3, K2 [48]
    Increase NGF H. erinaceus or ALCAR [49, 50]
    Provide synaptic structural components Citicoline, DHA [51].
    Optimize antioxidants Mixed tocopherols and tocotrienols, Se, blueberries, NAC, ascorbate, α-lipoic acid [52]
    Optimize Zn:fCu ratio Depends on values obtained [53]
    Ensure nocturnal oxygenation Exclude or treat sleep apnea [54]
    Optimize mitochondrial function CoQ or ubiquinol, α-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine [55]
    Increase focus Pantothenic acid Acetylcholine synthesis requirement
    Increase SirT1 function Resveratrol [32]
    Exclude heavy metal toxicity Evaluate Hg, Pb, Cd; chelate if indicated CNS effects of heavy metals
    MCT effects Coconut oil or Axona [56]"
    Reversal of cognitive decline in Alzheimer's disease 2016

    “MEND (metabolic enhancement for neurodegeneration):

    Eliminating all simple carbohydrates, gluten and processed food from the diet, and eating more organic vegetables, fruits and non-farmed fish
    Meditating twice a day and beginning yoga to reduce stress
    Sleeping seven to eight hours per night
    Taking melatonin, methylcobalamin, vitamin D3, fish oil and coenzyme Q10 each day
    Optimizing oral hygiene using an electric flosser and electric toothbrush
    Reinstating youthful hormone levels using hormone replacement therapy
    Fasting for a minimum of 12 hours between dinner and breakfast, and for a minimum of three hours between dinner and bedtime
    Exercising for a minimum of 30 minutes, four to six days per week

    Dr. Bredesen acknowledges that the approach is complex and most people want the magic of a pill. But there are no magic pills today.”
    "Don't sweat the small stuff and relax about the whole process"